BAX Antibody

BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction (PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria (PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis (PMID: 8183579).

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Category Antibodies
Publication 238
Application ELISA, FC, IF, IHC, IP, WB
Host Rabbit
Reactivity Human, mouse, rat, guinea pig, Rabbit, sheep
Clonality Polyclonal
Purification Protein A purification
immunogen BAX fusion protein Ag0576
Form PBS with 0.1% sodium azide and 50% glycerol pH 7.3 .
Storage Store at -20°C. Aliquoting is unnecessary for -20°C storage.
Supplier Proteintech
Isotype IgG
MW 21 kDa
Dilution WB : 1:2000-1:8000IP : 0.5-4.0 ug for IP and 1:1000-1:10000 for WBIHC : 1:20-1:200IF : 1:50-1:500
Catalog Number 50599-2-Ig
Alternative Names Apoptosis regulator BAX, BAX
Size 150ul
Gene Symbol BAX
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