BCL2 Antibody

BCL2 belongs to the Bcl-2 family. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. BCL2 regulates cell death by controlling the mitochondrial membrane permeability (PMID: 10365962). It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PMID: 10444588).

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Category Antibodies
Publication 248
Application ELISA, FC, IF, IHC, IP, WB
Host Rabbit
Reactivity Human, guinea pig, mouse, Rabbit, rat, sheep
Clonality Polyclonal
Purification Antigen affinity purification
immunogen BCL2 fusion protein Ag3508
Form PBS with 0.1% sodium azide and 50% glycerol pH 7.3 .
Storage Store at -20°C. Aliquoting is unnecessary for -20°C storage.
Supplier Proteintech
Isotype IgG
MW 26 kDa
Dilution WB : 1:1000-1:10000IP : 0.5-4.0 ug for IP and 1:500-1:5000 for WBIHC : 1:50-1:500
Catalog Number 12789-1-AP
Alternative Names Apoptosis regulator Bcl 2, B cell CLL/lymphoma 2, BCL2, BCL-2, Oncogene B cell leukemia 2
Size 150ul
Gene Symbol BCL2