TDP-43 Antibody

The TARDBP gene encodes the TDP-43 protein, initially found to repress HIV-1 transcription by binding TAR DNA. TDP-43 has since been shown to bind RNA as well as DNA, and have multiple functions in transcriptional repression, translational regulation and pre-mRNA splicing. For instance, it is reported to regulate alternate splicing of the CTFR gene. In 2006 Neumann et al. found that hyperphosphorylated, ubiquitinated and/or cleaved forms of TDP-43, collectively known as pathological TDP-43, play a major role in the disease mechanisms of ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in amyotrophic lateral sclerosis (ALS). Proteintech

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Category Antibodies
Publication 810
Application ELISA, ChIP, CoIP, FC, IF, IHC, IP, RIP, WB
Host Rabbit
Reactivity Human, mouse, rat, ZebraFish, C. elegans, Chicken, dog, Drosophila, fly, hamster, horse, monkey, recombinant protein, worm, Yeast
Clonality Polyclonal
Purification Antigen affinity purification
immunogen TDP-43 fusion protein Ag1231
Form PBS with 0.1% sodium azide and 50% glycerol pH 7.3 .
Storage Store at -20°C. Aliquoting is unnecessary for -20°C storage.
Supplier Proteintech
Isotype IgG
MW 43 kDa
Dilution WB : 1:1000-1:10000IP : 0.5-4.0 ug for IP and 1:200-1:2000 for WBIHC : 1:50-1:5000IF : 1:200-1:800
Catalog Number 10782-2-AP
Alternative Names ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43
Size 150ul
Gene Symbol TARDBP
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