PAX8 Antibody

PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX8 has 5 isoforms with calculated MW 31kd, 34kd, 41kd, 43kd and 48kd. And there is a 60kd band corresponding to the electrophoretic mobility of PAX8 (PMID:15650356). Proteintech

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Category Antibodies
Publication 202
Application ELISA, FC, IF, IHC, IP, WB
Host Rabbit
Reactivity Human, mouse, rat, bovine, ZebraFish
Clonality Polyclonal
Purification Antigen affinity purification
immunogen PAX8 fusion protein Ag0306
Form PBS with 0.1% sodium azide and 50% glycerol pH 7.3 .
Storage Store at -20°C. Aliquoting is unnecessary for -20°C storage.
Supplier Proteintech
Isotype IgG
MW 48 kDa
Dilution WB : 1:500-1:5000IP : 0.5-4.0 ug for IP and 1:500-1:5000 for WBIHC : 1:200-1:2000
Catalog Number 10336-1-AP
Alternative Names paired box 8, Paired box protein Pax 8, PAX8
Size 150ul
Gene Symbol PAX8