Anti-Glutamate Receptor 2 Antibody, extracellular, clone 6C4 | MAB397

Recognizes the large N-terminal extracellular domain of Glutamate Receptor 2 (GluR2). No cross-reactivity observed with other AMPA/Kainate GluR subunits. On western blots of brain extracts from rat, macaque monkey, and dog, MAB397 recognizes a band at approximately 102 kDa corresponding to full length GluR2. Other proteins noted by Western blot at 66 kDa or lower molecular weight appear to be breakdown products of GluR2 (Vissavajjhala, 1996). By immunohistochemistry GluR2 is widely distributed at both the cellular and synaptic levels. MAB397 recognizes GluR2 present in a vast majority of, but not all, GABAergic interneurons (Vissavajjhala, 1996).

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Category Antibodies
Publication 65
Application ELISA, IF/ICC, IHC, IP, RIA, WB
Host Mouse
Reactivity Mouse, Rat, Monkey, Canine
Clonality Monoclonal
Purification Purified immunoglobulin from culture supernatant
immunogen Recombinant fusion protein TrpE-GluR2 (putative N-terminal portion, amino acids 175-430).
Form Purified mouse immunoglobin IgG2a liquid in buffer containing PBS, no preservative.
Storage Stable for 6 months at -20ºC in undiluted aliquots from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage the IgG2a and affect product performance.
Supplier Millipore
Isotype IgG2a
MW 102 kDa
Catalog Number MAB397
Conjugation Unconjugated
Alternative Names Gria2,GLUR2,GLURB,GluR-2,GluR-B,GluR-K2
Size 100 µg
Clone 6C4