Anti-APP A4 Antibody, a.a. 66-81 of APP {NT}, clone 22C11

Reacts with pre-A4. The antibody recognizes amino acids 66-81 of the N-terminus on the pre-A4 molecule (Hilbich et al., 1993). 22C11 recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa (Hoffmann et al., 2000). The antibody is known to cross react with APLP2 (Slunt, 1994).

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Category Antibodies
Publication 126
Application IF/ICC, IHC, WB
Host Mouse
Reactivity Canine, Human, Mouse, Monkey, Pig, Rat, Fish
Clonality Monoclonal
Purification Protein A purfied
immunogen Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein.
Form Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Storage Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier Millipore
Isotype IgG1
MW 110/120/130 kDa
Catalog Number MAB348
Conjugation Unconjugated
Alternative Names APP,PN-II,AD1,ABETA,CTFgamma,APPI,ABPP,A4,CVAP,PN2,PreA4,AAA
Size 50 μg
Clone 22C11