Mouse Anti-Human Von Willebrand Factor Monoclonal Antibody, Alk. Phos. Conjugated, Clone RFF-VIII R/1

The Mouse Anti-Human Von Willebrand Factor Monoclonal Antibody, Alk. Phos. Conjugated, Clone RFF-VIII R/1 from GenWay Biotech, Inc. is a Mouse Monoclonal antibody to Clone RFF-VIII R/1 to von Willebrand factor. This antibody recognizes Human antigen. Mouse Anti-Human Von Willebrand Factor Monoclonal Antibody, Alk. Phos. Conjugated, Clone RFF-VIII R/1 has been validated for the following applications: ELISA. Function: Important in the maintenance of hemostasis. it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII. delivering it to the site of injury. stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.Subunit: Multimeric. Interacts with F8.Subcellular Location: Secreted. Note=Localized to storage granules.Tissue Specificity: Plasma.Domain: The von Willebrand antigen 2 is required for multimerization of VWF and for its targeting to storage granules.Ptm: All cysteine residues are involved in intrachain or interchain disulfide bonds.Disease: Defects in VWF are associated with various forms of von Willebrand disease (VWD) [MIM:193400. 277480]. VWD is characterized by frequent bleeding (gingival. minor skin quantitative lacerations. menorrhagia. etc.). Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. There are subtypes (A to H) of type II VWD; for example: type IIA is characterized by the absence of VWF high molecular weight multimers in plasma.Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain.Similarity: Contains 4 TIL (trypsin inhibitory-like) domains.Similarity: Contains 3 VWFA domains.Similarity: Contains 3 VWFC domains.Similarity: Contains 4 VWFD domains. Accession Number: CAA29985.1 SP Accession Number: P04275 Sequence Length (aa): 178 MW: 309299 OMIM: 193400; gene+phenotype. [ NCBI / EBI]277480; phenotype. [ NCBI / EBI] Applications Tested: E Storage: Store at +4C or at -20C if preferred.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we rec Stability: 12 months from date of despatch. Isotype: IgG1Clone: RFF-VIII R/1Specificity: VON WILLEBRAND FACTOR Preservative Stabilisers: 0.01% NaN350% glycerolBuffer Solution: Phosphate buffered saline Product ID: 74511

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Category Antibodies
Publication 0
Application ELISA
Host Mouse
Reactivity Human
Clonality Monoclonal
Supplier GenWay Biotech Inc.
Isotype IgG1
Catalog Number GWB-75620D
Conjugation Alk. Phos.
Size 1 ml
Tissue Location http://www.genwaybio.com/product_info.php?products_id=74511

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