TCF4 Antibody

LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1/TCF7), TCF3/TCF7L1, and TCF4/TCF7L2 (1). LEF1 and TCF1/TCF7 were originally identified as important factors regulating early lymphoid development (2) and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for ?-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling (3). LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers including colon cancer (4,5).

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Category Category: Primary Antibodies
Publication 0
Application Western Blotting,Immunoprecipitation,Chromatin IP
Specificity TCF4 Antibody detects endogenous levels of total TCF4 protein. It is expected to recognize most, if not all, human TCF4 splicing isoforms.
Host Rabbit
Reactivity Human
Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu330 of human TCF4. Antibodies are purified by protein A and peptide affinity chromatography.
Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100
Supplier Cell Signaling Technology
MW 58, 79
Dilution 1:1000,1:50,1:25
Catalog Number 2566
ELISA Sensitivity Endogenous
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