KCNQ1 antibody (ATTO-633)

Mouse monoclonal to KCNQ1 (ATTO-633). Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. Specifically, Kv7. 1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. Kv7. 1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons among other tissues. In the cardiac cells, Kv7. 1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction...

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Category Antibodies
Price £338
Publication 0
Application WB, IHC-P, IF/ICC, IP
Specificity Detects 75kDa.
Target KCNQ1
Host Mouse
Reactivity Human, Mouse, Rat
Clonality Monoclonal
Purification Protein G Purified
immunogen Fusion protein amino acids 2-101 of human KCNQ1, accession number P51787
Form PBS pH7.4, 50% glycerol
Storage Store at 2-8°C and -20°C for one year. (Shipped on ice packs)
Note For research use only.
Supplier Biorbyt
Isotype IgG1
Dilution WB:1-10 μg/ml , IHC-P:0.1-1.0 μg/ml, IF/ICC:1.0-10 μg/ml
Catalog Number orb148274
Concentration 1 mg/ml
Conjugation ATTO-633
Alternative Names anti ATFB1 antibody, anti ATFB3 antibody, anti FLJ26167 antibody, anti IKs producing slow voltage-gated potassium channel subunit alpha antibody, anti IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 antibody, anti Jervell and Lange-Nielsen syndrome 1 antibody, anti JLNS1 antibody, anti KCNA8 antibody, anti KCNA9 antibody, anti KCNQ1 antibody, anti KCNQ1_HUMAN antibody, anti kidney and cardiac voltage dependend K+ channel antibody, anti KQT-like 1 antibody, anti Kv1.9 antibody, anti Kv7.1 antibody, anti KVLQT1 antibody, anti long (electrocardiographic) QT syndrome antibody, anti Ward-Romano syndrome 1 antibody, anti LQT antibody, anti LQT1 antibody, anti Potassium voltage-gated channel subfamily KQT member 1 antibody, anti potassium voltage-gated channel KQT-like subfamily member 1 antibody, anti RWS antibody, anti slow delayed rectifier channel subunit antibody, anti SQT2 antibody, anti Voltage-gated potassium channel subunit Kv7.1 antibody, anti WRS antibody
Size 100 μg
Clone S37A-10

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