CaV3.2 antibody (ATTO-488)

Mouse monoclonal to CaV3 (ATTO-488). 2. Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand-gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. Specifically, CaV3. 2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy. Studies also suggest that the up-regulations of CaV3. 2 may participate in the progression of prostate cancer toward an androgen-independent stage. ...

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Category Antibodies
Price £338
Publication 0
Application WB, IF/ICC, IP
Specificity Detects 260kDa. No cross-reactivity against Cav1.3
Target CaV3.2
Host Mouse
Reactivity Human, Mouse, Rat
Clonality Monoclonal
Purification Protein G Purified
immunogen Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3.2, accession number O95180
Form PBS pH7.4, 50% glycerol
Storage Store at 2-8°C and -20°C for one year. (Shipped on ice packs)
Note For research use only.
Supplier Biorbyt
Isotype IgG1
Dilution WB:1-10 μg/ml , IHC-P:0.1-1.0 μg/ml, IF/ICC:1.0-10 μg/ml
Catalog Number orb148203
Concentration 1 mg/ml
Conjugation ATTO-488
Alternative Names anti Cav3.2 antibody, anti CACNA1H antibody, anti CACNA1HB antibody, anti calcium channel antibody, anti voltage-dependent antibody, anti T type antibody, anti alpha 1H subunit antibody, anti calcium channel antibody, anti voltage-dependent antibody, anti T type antibody, anti alpha 1Hb subunit antibody, anti ECA6 antibody, anti EIG6 antibody, anti FLJ90484 antibody, anti Low-voltage-activated calcium channel alpha1 3.2 subunit antibody, anti low-voltage-activated calcium channel alpha13.2 subunit antibody, anti voltage dependent t-type calcium channel alpha-1H subunit antibody, anti voltage-dependent T-type calcium channel subunit alpha-1H antibody, anti voltage-gated calcium channel alpha subunit Cav3.2 antibody, anti voltage-gated calcium channel alpha subunit CavT.2 antibody, anti Voltage-gated calcium channel subunit alpha Cav3.2 antibody
Size 100 μg
Clone S55-10

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