CaV1.3 antibody (RPE)

Mouse monoclonal to CaV1 (RPE). 3. Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. Specifically, CaV1. 3, also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), is a human gene. CaV1. 3 subunits are primarily expressed in neurons and neuroendocine cells. Some studies suggest however that CaV1. 3 is also found in the atria, and may figure prominently in atrial arrhythmias. CaV1. 3 also carries the primary sensory receptors of the mammalian cochlea, and are also expressed in the electromotile outer hair cells..

  • Product Detail
  • All Images
Category Antibodies
Price £335
Publication 0
Application WB, IF/ICC, IP
Specificity Detects 250kDa. No cross-reactivity against Cav1.2
Target CaV1.3
Host Mouse
Reactivity Human, Mouse, Rat
Clonality Monoclonal
Purification Protein G Purified
immunogen Fusion protein amino acids 2025-2161 of rat Cav1.3, accession number P27732
Form PBS pH7.4, 50% glycerol
Storage Store at 2-8°C and -20°C for one year. (Shipped on ice packs)
Note For research use only.
Supplier Biorbyt
Isotype IgG1
Dilution WB:1-10 μg/ml , IHC-P:0.1-1.0 μg/ml, IF/ICC:1.0-10 μg/ml
Catalog Number orb148200
Concentration 1 mg/ml
Conjugation RPE
Alternative Names anti alpha-1 polypeptide antibody, anti CAC1D_HUMAN antibody, anti CACH3 antibody, anti CACN4 antibody, anti CACNA 1D antibody, anti Cacna1d antibody, anti CACNL1A2 antibody, anti Calcium channel antibody, anti Calcium channel L type alpha 1 polypeptide isoform 2 antibody, anti Calcium channel neuroendocrine/brain type alpha 1 subunit antibody, anti Calcium channel voltage dependent L type alpha 1D subunit antibody, anti CCHL1A2 antibody, anti isoform 2 antibody, anti L type antibody, anti Voltage dependent L type calcium channel subunit alpha 1D antibody, anti Voltage gated calcium channel alpha 1 subunit antibody, anti Voltage gated calcium channel alpha subunit Cav1.3 antibody, anti Voltage gated calcium channel subunit alpha Cav1.3 antibody, anti Voltage-dependent L-type calcium channel subunit alpha-1D antibody, anti Voltage-gated calcium channel subunit alpha Cav1.3 antibody
Size 100 μg
Clone S38-8

Images are not available.