Purified anti-C/EBPα Antibody

The CCAAT-enhancer binding proteins (C/EBP) are members of the basic region/leucine zipper (bZIP) transcription factors, that bind to the consensus CCAAT sequence in DNA. C/EBPα is expressed in two isoforms: p42 and p30 by ultilizing different translational start codons. The C/EBPα p30 isoform has little to no transactivating activity and acts as an inhibitor. C/EBPα regulates expression of various myeloid-specific genes and is required for myeloid differentiation. C/EBPα has been found to play a key role in adipogenesis, since inhibition of C/EBPα blocks adipocyte differentiation. C/EBPα also regulates cell cycle progression through interactions with cyclin-dependent kinases (CDK) and by inducing the expression of CDK inhibitor p21. Mutations in the C/EBPα gene are associated with the development of acute myeloid leukemia.

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Category Antibodies
Price $225.00
Publication 6
Application WB, IF
Host Mouse IgG2a, κ
Reactivity Human, weakly cross-reacts with mouse
Purification The antibody was purified by affinity chromatography.
immunogen Synthetic peptide (AKQLALAGLFPYQPPPP) conjugated to KLH.
Form Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Storage The antibody solution should be stored undiluted between 2°C and 8°C.
Supplier Biolegend
Isotype Mouse IgG2a, κ
Dilution Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Catalog Number 662102
Concentration 0.5 mg/ml
Alternative Names CCAAT/enhancer-binding protein alpha, C/EBP-A
Size 100 µg
Clone 16C12B70
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