Caspase-8 Antibody

Abbiotec's Caspase-8 Antibody is a Rabbit Polyclonal antibody. The Caspase-8 Antibody was generated using MACH, Caspase-8, FLICE, Casp-8, CAP4, ALPS2B, CASP8, caspase 8, apoptosis-related cysteine peptidase, Mch5 as the antigen and it reacts with Bovine, Hamster, Human, Canine, Rat, Mouse. This antibody has been shown to work in applications such as: ELISA, Western Blot, Immunohistochemistry. Caspase-8 is the most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Caspase-8 binding to the adapter molecule FADD recruits the complex to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) triggers caspase-8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. The enzyme then cleaves and activates caspase-3, caspase-4, caspase-6, caspase-7, caspase-9 and caspase-10. Granzyme B and CPP32 cleave caspase-8 at Asp 315 and Asp 330 respectively to generate the two active subunits

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Category Antibodies
Publication 0
Application ELISA, WB, IHC
Host Rabbit
Reactivity Human, Mouse, Rat, Hamster, Canine, Bovine
Clonality Polyclonal
immunogen KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of rodent Caspase-8
Supplier Abbiotec
Isotype Ig
Catalog Number 250576
Conjugation Unconjugated
Size 0.1 mg
Tissue Location http://www.abbiotec.com/antibodies/caspase-8-antibody

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