APP Antibody

The APP Antibody from Abbiotec is a Mouse Polyclonal antibody to PN-II, Abeta, ABPP, APP, AD1, amyloid beta (A4) precursor protein, PN2, CTFgamma, Cvap, APPI, AAA. This antibody recognizes Human, Rat, Mouse antigen. The APP Antibody has been validated for the following applications: ELISA, Immunohistochemistry, Western Blot, Immunoprecipitation. The Amyloid Protein Precursor (APP) is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, whereas others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). In addition, APP is associated with neurological disorders related to type II diabetes and Down's syndrome

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Category Antibodies
Publication 0
Application ELISA, WB, IHC, IP
Host Mouse
Reactivity Human, Rat, Mouse
Clonality Polyclonal
immunogen KLH-conjugated synthetic peptide encompassing the human APP695 sequence
Supplier Abbiotec
Isotype Ig
Catalog Number 250545
Conjugation Unconjugated
Size 0.1 mg
Tissue Location http://www.abbiotec.com/antibodies/app-antibody

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