SYK Antibody

The SYK Antibody from Abbiotec is a Rabbit Polyclonal antibody to spleen tyrosine kinase, p72-Syk, Syk. This antibody recognizes Human, Bovine, Canine, Porcine, Rat, Mouse antigen. The SYK Antibody has been validated for the following applications: ELISA, Western Blot, Immunohistochemistry. SYK (Spleen tyrosine kinase), along with Zap-70, is a member of the Syk family of cytoplasmic tyrosine kinases that contain a dual SH2 domain separated by a linker region. In B cells, SYK couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through phosphorylation/activation of phospholipase C-gamma, when phosphorylated on Tyr-348 and Tyr-352. Phosphorylation on Tyr-323 creates a binding site for c-Cbl, which is a negative regulator of BCR-stimulated calcium signaling. Also transmits signals from other cell surface receptors including the T-cell receptor, CD74, Fc receptor, and integrins. Abnormal constitutive SYK activity has been implicated in some hematopoietic malignancies

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Category Antibodies
Publication 0
Application ELISA, WB, IHC
Host Rabbit
Reactivity Human, Mouse, Rat, Bovine, Pig, Canine
Clonality Polyclonal
immunogen KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SYK
Supplier Abbiotec
Isotype Ig
Catalog Number 250530
Conjugation Unconjugated
Size 0.1 mg
Tissue Location http://www.abbiotec.com/antibodies/syk-antibody

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