Glutamate Decarboxylase Antibody

Abbiotec's Glutamate Decarboxylase Antibody is a Rabbit Polyclonal antibody. The Glutamate Decarboxylase Antibody was generated using glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa), Glutamate decarboxylase, GAD2, GAD65 as the antigen and it reacts with Human, Canine, Porcine, Chicken/Bird, Rat, Mouse, Bovine. This antibody has been shown to work in applications such as: Western Blot, Immunohistochemistry, ELISA. GAD65, an autoantigen in type I diabetes, is transiently activated in response to the demand for extra GABA in neurotransmission, and cycles between an active holo form and an inactive apo form. An inherently mobile catalytic loop promotes a side reaction that results in cofactor release and GAD65 autoactivation