Gliadin Peptide (14D5) Antibody

The Gliadin Peptide (14D5) Antibody from Abbiotec is a Mouse Monoclonal antibody to 14D5 to Gliadin. This antibody recognizes Plant antigen. Gliadin Peptide (14D5) Antibody has been validated for the following applications: ELISA. Celiac disease is associated with a CD4+ T-cell response to epitopes of gliadin presented by HLA-DQ2 or -DQ8 class II MHC molecules. These epitopes are present in a 33-mer peptide of wheat alpha-gliadin, residues 56-88, which is resistant to digestion and forms a substrate for tissue transglutaminase (TG2), generating the glutamic acid residues essential for binding to HLA-DQ2. The immunogen corresponds to a deamidated form of a region that includes the T-cell epitopes, including the immunodominant PQPQLPY region and two PXPQP motifs associated with binding to IgA from patients with celiac disease. Complete homology exists between residues 63-73, 70-80 and 77-87 of wheat alpha gliadin. This antibody reacts strongly with the deamidated peptide but cross-reacts about 5% with the non-deamidated peptide KLQPFPQPQLPYPQPQ

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Category Antibodies
Publication 0
Application ELISA
Host Mouse
Reactivity Plant
Clonality Monoclonal
immunogen Gliadin-related peptide Lys57-Glu65-[alpha-gliadin (58-73)] (KLQPFPQPELPYPQPQ) coupled to immunogenic carrier protein
Supplier Abbiotec
Isotype IgG2a lambda
Catalog Number 250437
Conjugation Unconjugated
Size 0.2 mg
Tissue Location

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