Acetylcholinesterase (4E11) Antibody

Abbiotec's Acetylcholinesterase (4E11) Antibody is a Mouse monoclonal antibody (clone 400000000000). The Acetylcholinesterase (4E11) Antibody was generated using acetylcholinesterase, ARACHE, ACEE, YT, AChE, N-ACHE as the antigen and it reacts with Porcine, Rabbit, Sheep, Human, Feline, Non-Human Primate, C. elegans/Worm, Bovine, Donkey, Hamster, Mouse, Rat, Guinea Pig, Horse, Other Mammalian, Canine, Goat. This antibody has been shown to work in applications such as: ELISA, Western Blot. Acetylcholinesterase (AChE, EC.3.1.1.7.) is an enzyme located in the postsynaptic membrane and in the muscle endplates, where it hydrolyses the neurotransmitter acetylcholin. AChE from brain is a tetramer (G4-AChE) with a molecular mass of 320 kDa, AChE from erythrocytes is a dimer (G2-AChE) with a molecular mass of 170 kDa. Detection of higher levels of AChE in amniotic fluid can indicate fetal malformations such as neural tube defects. This antibody is specific for brain AChE and does not recognize AChE from erythrocytes. The antibody can thus distinguish between mammalian brain AChE and erythrocyte AChE. There is a weak cross-reactivity with Torpedo marmorata AChE but none with AChE from electric eel or human BtChE

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Category Antibodies
Publication 0
Application ELISA, WB
Host Mouse
Reactivity Human, Bovine, Mouse
Clonality Monoclonal
immunogen C-terminal 10 residues of brain acetylcholinesterase (human and bovine), absent from the erythrocyte enzyme
Supplier Abbiotec
Isotype IgG1 kappa
Catalog Number 250379
Conjugation Unconjugated
Size 0.2 mg
Tissue Location http://www.abbiotec.com/antibodies/acetylcholinesterase-4e11-antibody

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