C3 Complement beta-chain variant (8G4) Antibody

The C3 Complement beta-chain variant (8G4) Antibody from Abbiotec is a Mouse Monoclonal antibody to 8G4 to AHUS5, complement component 3, C3b, ASP, C3, CPAMD1, ARMD9, C3a. This antibody recognizes Human antigen. C3 Complement beta-chain variant (8G4) Antibody has been validated for the following applications: ELISA, Western Blot. C3 is a key component of the complement system since classical and alternative activation pathways merge at the C3 activation step when C3 is split into C3a and C3b. The molecular mass of C3 is 185 kDa and it consists of alpha and beta chains (110 kDa and 75 kDa respectively) held together by disulfide bonds. This antibody is specific for an allotypic marker on human C3 (Leu instead of Pro in codon 314 of exon 9), which occurs regularly in the beta-chain of C3F and occasionally in the beta-chain of C3S (F and S meaning fast and slow migration rate, respectively, on agarose gel electrophoresis). The antibody reacts with the 75-kDa beta-chain band of reduced C3 in immunoblotting, and reacts with the 20-kDa and 17-kDa beta-chain fragments produced by cyanogen bromide cleavage

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Category Antibodies
Publication 0
Application ELISA, WB
Host Mouse
Reactivity Human
Clonality Monoclonal
immunogen C3 isolated from human plasma
Supplier Abbiotec
Isotype IgG2a kappa
Catalog Number 250286
Conjugation Unconjugated
Size 0.1 mg
Tissue Location http://www.abbiotec.com/antibodies/c3-complement-beta-chain-variant-8g4-antibody

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