Collagen Type I (5D8) Antibody

The Collagen Type I (5D8) Antibody from Abbiotec is a Mouse Monoclonal antibody to 5D8 to Collagen Type I, collagen, type I, alpha 1, COL1A1, OI4. This antibody recognizes Human antigen. Collagen Type I (5D8) Antibody has been validated for the following applications: Western Blot, ELISA, Immunohistochemistry. Type I collagen is present in connective tissue and bone where it makes up about 90% of the organic matrix. Defects in one or both alleles of the type I collagen gene causes "brittle bone disease" (osteogenesis imperfecta). Patients suffering from such defects have low levels of fully functional type I collagen resulting in fragile bones. This antibody is highly specific for native type I collagen and shows no evidence of cross-reactivity with type II, III, V and VI collagens in inhibition ELISA and immunoblotting, and no evidence of cross-reactivity with other connective tissue proteins (laminin, fibronectin, elastin). The antibody reacts with human, calf, sheep, pig, dog and goat type I collagens in ELISA and immunoblotting, but does not react with mouse, guinea pig, cat, rabbit, squirrel, horse, kangaroo or chicken type I collagen. The antibody has a Ka of approximately 2.5 x 106 M-1 for human type I collagen

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Category Antibodies
Publication 0
Application ELISA, WB, IHC
Host Mouse
Reactivity Human
Clonality Monoclonal
immunogen Pepsin-solubilized, salt-fractionated type I collagen from human placenta
Supplier Abbiotec
Isotype IgG1 kappa
Catalog Number 250274
Conjugation Unconjugated
Size 0.2 mg
Tissue Location http://www.abbiotec.com/antibodies/collagen-type-i-5d8-antibody

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