Factor B Antibody

Abbiotec's Factor B Antibody is a Mouse monoclonal antibody (clone KT21). The Factor B Antibody was generated using CFAB, FB, AHUS4, H2-Bf, BF, GBG, Factor B, CFB, Complement factor B, PBF2, BFD, FBI12 as the antigen and it reacts with Human. This antibody has been shown to work in applications such as: ELISA. The complement factor B is part of the alternate pathway of the complement system. Factor B is cleaved by factor D into two fragments, Ba and Bb, the latter being a serine protease that binds to complement component 3b (C3b) to generate the C3 or C5 convertase. Factor B is involved in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. Among the 15 variants of factor B gene, the variants His-9 and Gln-32 are associated with a reduced risk of age-related macular degeneration (ARMD). This antibody recognizes human complement factor B in indirect and sandwich ELISA