NBS1 Antibody

The NBS1 Antibody from Abbiotec is a Rabbit Polyclonal antibody to Nibrin, p95, AT-V2, NBS, AT-V1, ATV, NBN, Nbs1. This antibody recognizes Mouse, Rat, Xenopus/Amphibian, Human antigen. The NBS1 Antibody has been validated for the following applications: ELISA, Western Blot. Nijmegen breakage syndrome protein 1 (NBS1) is a component of the MRE11/RAD50/NBN (MRN) complex, which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. NBS1 modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. Defects in NBS1 are the cause of Nijmegen breakage syndrome, cancer predisposition, and anemia

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Category Antibodies
Publication 0
Application ELISA, WB
Host Rabbit
Reactivity Human, Mouse, Rat, Xenopus
Clonality Polyclonal
immunogen KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NBS1
Supplier Abbiotec
Isotype Ig
Catalog Number 200163
Conjugation Unconjugated
Size 0.1 mg
Tissue Location http://www.abbiotec.com/antibodies/nbs1-antibody

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